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Pharmacoepidemiology and Drug Safety

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Unfortunately leptin mimetics have failed to provide significant weight loss outside the cases of leptin-replacement therapy for patients with genetic leptin deficiency [12, 13]

When compared to other strategies, GLP-1R agonists occupy an intermediate position, more effective than lifestyle or other pharmacological interventions, but less invasive than bariatric surgery, underscoring their unique therapeutic niche

3.2 Adherence to Interventions After the low-calorie diet, the structured exercise program started with a gradual increase in exercise volume over the first 6 weeks after randomization