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Since ceruloplasmin binds 85-95% of circulating copper and facilitates its safe transport, reduced synthesis means a higher fraction of "free" (non-ceruloplasmin-bound) copper in circulation

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For hair applications specifically, longer cycles of 12-16 weeks may be appropriate given the slow nature of hair regrowth, followed by 4-6 week breaks

Patients often report a gradual but positive change over weeks of therapy

BioMed Research International (2015) 3

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