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As these small tears accumulate, the tendons become weaker, less elastic, and more prone to further injury a condition known as degenerative tendinopathy

Nat Immunol (2015) 16(5):44857.10.1038/ni.3153 103 KremerJMBlancoRBrzoskoMBurgos-VargasRHallandAMVernonEet alTocilizumab inhibits structural joint damage in rheumatoid arthritis patients with inadequate responses to methotrexate: results from the double-blind treatment phase of a randomized placebo-controlled trial of tocilizumab safety and prevention of structural joint damage at one year

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Liraglutide for diabetes (Victoza) starts at 0.6 mg daily, and liraglutide for weight management (Saxenda) escalates from 0.6 mg to 3.0 mg daily

Protocol and timing both matter

Demidova-Rice TN, Hamblin MR, Herman IM