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Nigam SK, Wu W, Bush KT, Hoenig MP, Blantz RC, Bhatnagar V (2015) Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters

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More serious side effects include lactic acidosis, which is, however, very rare and is reduced by avoiding its use in patients with severe renal and liver dysfunction (9, 1115)

This constraint can pose significant challenges for individuals with chronic ailments, necessitating extended therapeutic interventions

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