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Furthermore, growing evidence suggests that the dysbiosis of the gastrointestinal tract may eventually contribute to the impairment of intestinal mucosal integrity, instigate a high-level inflammation response, affect the bile acids cross-talk, and disrupt minerals absorption ratethereby, hastening the evolution of OP

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J Crohns Colitis 14:422 Tran CD, Howarth GS, Coyle P, Philcox JC, Rofe AM, Butler RN (2003) Dietary supplementation with zinc and a growth factor extract derived from bovine cheese whey improves methotrexate-damaged rat intestine

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