The closest structural relative was found to be human CLIC1 (PDB code 1K0O), in which 156 C could be aligned with a root-mean-square deviation (RMSD) value of 0.93 , followed by GSTO1 from Homo sapiens (PDB code 3LFL) (122 aligned C with an RMSD of 2.07 ) and the putative stringent starvation protein A from Burkholderia cenocepacia (PDB code 4QQ7) (122 aligned C with an RMSD of 2.14 ) 12,15
It describes them as typically mild to moderate and often resolving within days to weeks, and notes the experience is inconsistent: some patients report none at all while others get them only transiently
Also, does not need refrigeration
Moreover, the model asserts that control of the proton gradient across the mitochondrial inner membrane is rate-limiting upon fitness management of SDH-b deficient cells
Ammonia is released as a result of the transformation of glutamine into glutamate [78, 79]
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