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Previous studies of KBP-089 using pair-feeding have demonstrated a weight loss beyond what is obtained through the reduction of appetite, and have clearly indicated that this effect likely entails increased energy expenditure, or at least a maintenance of energy expenditure, despite the reduction of food intake, a parameter known to reduce energy expenditure [12, 17, 29, 43]

Data showed that GLP-1 significantly increased PI3K, Akt, and mammalian target of rapamycin (mTOR) phosphorylation without inducing the expression of PI3K, Akt, or mTOR

Updated 02/20/2020

Gastrointestinal conditions can affect both drug absorption and tolerability

Avoid strenuous exercise and heat exposure (saunas, hot tubs) for at least 24-48 hours