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Patients included in the trial had HbA1c 7 to 10% and were treated with either: diet and exercise alone or 1 to 3 oral antidiabetic drugs (metformin, sulfonylurea, glitazone or sodium-glucose co-transporter 2 inhibitor)

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A randomized controlled clinical trial (NCT01934777) involving children with non-alcoholic steatohepatitis (NASH) evaluated the effects of combined supplementation with docasahexaenoic acid, choline, and vitamin E (DHA-CHO-VE) (160)

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Glutamine, but not leucine, was found to activate mTORC1 by a pathway requiring the ADP ribosylation factor-1 GTPase and vacuolar adenosine triphosphatase for mTORC1 translocation and fixation, respectively, to the lysosomal membrane

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