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Additionally, there is no data addressing outcomes in patients who do not need weight loss but are using GLP-1 agonists solely to improve metabolic health

But the presence of additional ingredients can affect tolerability

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Diabetes alone can cause gastroparesis, but even after excluding people with diabetes, the researchers still found a signal

Kidney damage is a potential side effect, particularly due to dehydration caused by symptoms such as nausea, vomiting, or diarrhea