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For the IV drug (injected directly into the systemic circulation), the concentration starts at the highest point, and over time decreases as the drug is eliminated (remember, elimination means metabolism and excretion)
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The first group comprises glutathione disulfide substrates (GSSR) that are reduced by one molecule of GSH, yielding a thiol (RSH) and glutathione disulfide (GSSG) as products (Fig
Studies also show that glutathione may reduce the risk of hepatitis and liver disease by reducing strain on the liver
