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Treatment with BCATi resulted in lower concentrations of both M0 (Figure 6D) and M5 (Figure 6E) KIV in skeletal muscle and plasma compared with untreated Mmut WT/WT mice

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A weight loss of at least 10% was achieved by 22.6% of patients in the twice-daily group, 17.4% in the once-daily group, and 9.7% in the placebo group