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doi: 10.1542/peds.2023-061501

Due to its naturally short half-life, it has been modified through the addition of a Drug Affinity Complex (DAC)

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Pancreatitis, gallbladder disease, and possible thyroid C-cell concerns have been discussed in clinical literature

Circulating Tumor DNA (ctDNA) for Surveillance Liquid biopsy technologies to detect ctDNA from NF1-deficient or TP53-mutant clones are being developed for monitoring disease recurrence or transformation in high-risk NF1 patients