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Eur J Endocrinol 156:263269

For instance, vitamin B12 activates succinyl-CoA

In germ-free mice, granulocyte and monocyte production is reduced in the bone marrow, but administration of bacterial-derived components such as lipopolysaccharide (LPS) or peptidoglycan (PGN) restores myelopoiesis (Yang et al., 2023)

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Gregory Lubiniecki, vice president of oncology clinical research at Merck Research Laboratories, noted in a statement that prognoses are generally poor for this disease and said the company is pleased to offer a new first-line treatment option. The approval was backed by results from the Phase II/III KEYNOTE-483 trial, where Keytruda elicited a significant survival benefit for patients, cutting the risk of death by 21%

This uncertainty is not a reason to dismiss the combination entirely