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Splitting ALA into smaller doses may help reduce gastrointestinal side effects, especially at higher intakes.43 Taking ALA with food can also improve tolerability though some studies suggest it may slightly reduce absorption.13 44 That tradeoff may be worth it for users sensitive to GI effects, particularly when taking ALA long-term

Thyroid hormone and gamma-aminobutyric acid (GABA) interactions in neuroendocrine systems

10.1787/9789264071001-en 35 OECD (2008)

Its half-life is generally considered relatively short, often around a few hours or less

(August 19, 2015)