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Mitochondrial signalling: MOTS-c is the only compound in the group targeting the AMPK/SIRT3 axis, addressing the metabolic driver of epithelial dysfunction
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Unlike stimulant appetite suppressants like phentermine that induce stereotypic behaviors and head-weaving, tesofensine causes minimal stereotypy at therapeutic doses, indicating a more refined pharmacological profile with reduced central stimulation side effects while maintaining robust anti-obesity efficacy
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