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Long-term safety and efficacy of the sodium-glucose cotransporter 2 inhibitor, tofogliflozin, added on glucagon-like peptide-1 receptor agonist in Japanese patients with type 2 diabetes mellitus: a 52-week open-label, multicenter, post-marketing clinical study

long-term safety in humans is not established

A properly reconstituted vial may take 10 to 20 minutes to clear completely

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Recently, a mouse model for the most common Weaver syndrome missense variant, EZH2 p.R684C was developed, and mouse embryonic fibroblasts (MEFs) obtained from these animals showed global depletion of H3K27me3