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Incremental AUC of blood glucose level markers for two hours were selected for measures of treatment effects

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10.1074/jbc.M115.705160

0.620.81) ( Regarding GLP-1 RAs, the LEADER, SUSTAIN-6, REWIND, PIONEER 6 and AMPLITUDE-O studies have shown nephroprotective effect, especially in preventing the occurrence of macroalbuminuria

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Patients with Hepatic Impairment In patients with moderate hepatic impairment (Child-Pugh score 7 to 9), mean AUC and Cmax of sitagliptin increased approximately 21% and 13%, respectively, compared to healthy matched controls following administration of a single 100-mg dose of sitagliptin