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How well they work can vary from person to person, so treatment should be individualized with guidance from a healthcare provider

Hydration status: reduced intake can increase dehydration risk

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Phase 2 trial data published in 2023 showed participants receiving the highest retatrutide dose lost an average of approximately 24 percent of body weight over 48 weeks, which exceeded results seen with dual-agonist medications in comparable timeframes

It also improves insulin sensitivity, which is key for reversing PCOS symptoms like weight gain, cravings, fatigue, and irregular periods