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It bypasses first-pass hepatic metabolism which oral delivery does not allowing a greater proportion of the absorbed peptide to remain intact as it enters circulation.7 The olfactory pathway also provides a potential direct nose-to-brain route, bypassing the blood-brain barrier a property that has generated interest for neuropeptides and potential neurological applications

At age 50, everyone, regardless of diet should start supplementing with B12-fortified foods or supplements but over age 65 only high-dose daily supplements may suffice

If you know your protocol will reach 7.5mg or higher, consider the 1ml reconstitution from the start

doi:10.3945/ajcn.111.020230

Always consult with a healthcare professional to determine your individual needs and the safest approach to B12 supplementation

Its also great for stress relief and relaxation