GLP-1RAs have pleiotropic effects: they improve neurogenesis, reduce apoptosis, protect neurons from oxidative stress, and reduce neuroinflammation in various neurological conditions, and it is these beneficial effects that can be used in aging-related diseases, mainly AD and PD
The cells were continuously superfused at a rate of 60 l/min with EC4 (ESM Table 2)
Qi L, Gao R, Chen Z, Lin D, Liu Z, Wang L, et al
Very different results and very different timelines
GLP-1 medications reduce overall food intake, and many patients naturally reduce refined carbohydrate consumption as appetite suppression shifts food preferences toward higher-protein, lower-sugar options
2A,B), as expected if Y1-R agonism by GEP44 serves to counteract GLP-1R agonism by the same peptide