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Simultaneously, DAG is believed to activate protein kinase C (PKC), a family of enzymes implicated in various cellular functions

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Although there is no clear relationship between specific GLP-RA Semaglutide and the risk for retinopathy according to the SUSTAIN-6 and a series clinical observations (possibly due to the inappropriate administrative manner), however, the other GLP-1Ras did not receive these reports, and real-world evidence further supports the use of GLP-1 agonists could potentially reduce DR risk and progression (106)

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The "best" depends on which pathway a protocol targets