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The initial pivotal studies that led to the first wave of GLP-1 RAs demonstrated that they work in several ways, including stimulating insulin release, slowing digestion, reducing appetite, and inhibiting glucagon release

PMID: 26701796

Studies using radiolabeled GA demonstrate that the gastrointestinal tract and thyroid gland contain the highest GA levels, with lowest levels in the CNS

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PlexusDx's Precision Peptide Genetic Test analyzes 14 distinct pathways and 49 peptides, including variants in the GLP1R gene (rs6923761), GIPR gene (rs1800437), and FTO gene (rs9939609)all directly relevant to how your body responds to semaglutide

& Schulz, R