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That's significantly higher than what's seen with diet-based weight loss alone

The FTO rs9939609 variant also influences metabolic rate and fat storage preferences, affecting how readily your body regains weight post-treatment

Notably, GLP-1 receptors are not confined to the pancreas

Decreased activity of the mitochondrial respiratory chain was reported in overweight/obese patients with NASH compared to controls [97, 98], and alterations in mitochondrial ultrastructure have been observed prior to NAFLD development in the Otsuka LongEvans Tokushima Fatty rat [99] as well as in patients with steatosis preceding progression to NASH [100]