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The selective mechanism is particularly valuable because it avoids the collateral damage to healthy cells that occurs with cytotoxic chemotherapy approaches to senescent cell elimination

Associated datasets are provided in Supplementary Tables 18

Imbalance toward GIP receptor, combined with distinct signaling properties at the GLP-1 receptor, together may account for the promising efficacy of this investigational agent

This is a frequency change, not a dose change, and is preliminary (PMC12210098)

Hypersensitivity Reactions: Anaphylaxis or angioedema has been reported in clinical trials

Outcome model: logistic regression at week 72