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doi:10.1200/JCO.2012.44.8738 38
GLP-1 medications work in part by slowing down digestion and changing how quickly food moves through the stomach
Tell your doctor if you have a history of thyroid cancer, type 1 diabetes, pancreatitis, multiple endocrine neoplasia syndrome type 2 (MEN 2) or depression, as Ozempic would not be the right choice for you
This animal work was approved by the Animal Care and Use Committee of the Shanghai Jiao Tong University School of Medicine
Results Dual function of GLP-1 receptor agonist peptide and anti-PCSK9 antibody fusions Based on the critical requirement for a free N-terminus on the GLP-1 peptide for receptor activation 11 , we genetically fused a DPP-4-resistant GLP-1R agonist peptide, similar to the one used in the Fc fusion molecule LY2189265 12 , to either the heavy or light chain variable domain of neutralising anti-PCSK9 antibodies (Fig
