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Impaired healing of a cutaneous wound in an inducible nitric oxide synthase-knockout mouse

If metformin is contraindicated or not tolerated, offer an SGLT-2 inhibitor and consider adding either: a GLP-1 receptor agonist for its cardiovascular, renal and glycaemic benefits or tirzepatide for its glycaemic benefits (5) Adults living with obesity If considering medicines primarily for weight management, see information about medicines for overweight and obesity in NICE's guideline on overweight and obesity management

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GLP-1 receptors are abundantly expressed in the pancreas, intestine, and central nervous system

Y., Guo, H