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MOTS-c has a half-life of 46 hours and works best when administered during metabolic windows where AMPK activation is already primedfasted states, pre-training, or during caloric deficit periods

They might just give you that extra push you need, but they work best when you're already doing the other healthy stuff

And quite often, it points to the same thing: low vitamin B12

However, in a subanalysis of participants with low vitamin B 12 status at baseline (n= 101), the B-vitamin supplementation slowed the decline in bone mineral density (total hip and femoral neck but not lumbar spine) (116)

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But there is much debate on how we can best supplement these vitamins outside of diet alone