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It comes from hemoglobin during the breakdown of old red blood cells

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doi: 10.3389/fphar.2024.1276551 Summary Keywords epilepsy-depression comorbidity, neuroinflammation, gut-brain axis, natural anti-inflammatory agents, aging-related inflammation Citation Shi Y-Q, Yang H-C, He C, Wang Y-H, Zheng J, Wang X-Y, Hao F-Y, Feng C-W, Ma L, Zhang Y-H and Liu Z (2025) Inflammatory links between epilepsy and depression: a review of mechanisms and therapeutic strategies

We discuss a systems-based framework for diagnosing and treating the root causes of disease, rather than simply managing symptoms

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