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Patients well-controlled on existing therapy should remain on their current regimen
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For newly diagnosed type 2 diabetes patients, current ADA guidelines support initial combination therapy when A1c is 1.5% above target
Side effect rates vary significantly by trial population
Metab Clin Exp 36(7):677682
Human -glutamyl transpeptidase mutants involving conserved aspartate residues and the unique cysteine residue of the light subunit
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