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12.5 mg and 15 mg (maximum doses): At these levels, the side effect profile is well-established for each individual

Changes are typically subtle initially, becoming more apparent over weeks

The decision to terminate the clinical trial early was based on the recommendation of independent Data Monitoring Committee (DMC), which concluded that the results from an interim analysis met certain pre-specified criteria for stopping the trial early for efficacy [2]

Follow appropriate laboratory handling procedures after reconstitution

10.1038/s41380-020-0762-0 128 WangY.MandelkowE

Ketohexokinase-A acts as a nuclear protein kinase that mediates fructose-induced metastasis in breast cancer