In this state, mutations of the APP gene augment the assembly of aberrant insoluble A, leading to the formation of amyloid plaque (Tomiyama and Shimada 2020)
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Additionally, semaglutide has also been found to reduce plasma concentrations of interferon- and tumor necrosis factor- (TNF-), while simultaneously lowering mRNA expression levels of cytokines such as chemokine ligand 2, interleukin-6 and vascular cell adhesion molecule-1 [31]
