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doi: 10.2174/0115734021398680251001102514 40

1 2 "GIP and GLP-1, the two incretin hormones: Similarities and differences"

Adults on GLP-1 receptor agonists for extended periods show reduced risk of cognitive decline and dementia in several observational and trial datasets, with effect sizes ranging from modest single-digit reductions to much larger ones, depending on the cohort

These cerebral actions of GLP-1 are unlikely to reflect the actions of peripherally produced GLP-1 but are rather targets for GLP-1 produced in and released from projections of neurons of the nucleus of the solitary tract, which express the proglucagon gene and have a processing pattern like the L cells of the gut

Weight loss includes some loss of lean body mass from bones and muscles