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Additionally, the sample size is small, attributable to the strict standards dogs must have met to be enrolled in the previously mentioned study, the duration of therapy, and the fact that three out of seven initially tested dogs were revealed to be receiving a placebo once the trial was unblinded

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The relevance of NAD + -boosting strategies for mitochondrial homeostasis and implications for health benefits in the context of aging and disease in preclinical and clinical studies will be discussed in the Preclinical and clinical applications of NAD + -modulating interventions for mitochondrial homeostasis and health benefits section