For most cells, access to selenium is easy because there are not many enzymes that require selenium as a building block, and so the synthesis of antioxidative stress enzymes and molecules proceeds unimpeded
It participates in methyl transfer and folate metabolism in the body, and promotes the conversion of 5-methyltetrahydrofolate to tetrahydrofolate
Response: We thank the commenter for their support
Metabolic regulation pathway research
Collectively, these compositional shifts implicate multiple functional pathways relevant to CHE, including short-chain fatty acid production (e.g., Lachnospiraceae , Eubacterium ) [72], inflammatory signaling and microbial product-related pathways (e.g., Enterobacteriaceae , Streptococcaceae ) [73], and ammonia or nitrogen metabolism (e.g., Clostridiales ) [74], rather than a single dominant mechanism
2022, www.nature.com/articles/s41591-022-02026-4 Garvey, W