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Do not substitute it for an insulin or injection unless a healthcare professional has changed your treatment plan

The dose conversion data suggests that maximum semaglutide roughly corresponds to tirzepatide 10-15mg, so maximum tirzepatide provides meaningfully more metabolic stimulus than maximum semaglutide

Available from: Ozturk M, Ipekci A, Kiyak SK, et al

WHO/CDS/WHOPES/GCDPP/2005.13

It is likely due to rapid ROS generation resulting in inducing oxidative stress beyond the cell capacity