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The mechanism by which amylin slows gastric emptying is still unknown, but evidence from animal studies suggests that amylin may influence the efferent activity of the vagus nerve via neurons in the brainstem

Open 7 , e2350408e2350408 (2024)

15 Conclusion Definitive conclusions regarding natural compounds remain challenging due to variations in formulation, routes of administration, and the limited size of clinical studies

Could be a contamination issue Genetic susceptibility Possible mechanisms exist but isolated to in vitro or animal high dose studies