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Consistently, the mRNA and protein levels of hepatic CYP8B1 were elevated, while the percentage of 12-OH BAs was increased and the proportion of non-12-OH BAs was reduced in the gallbladder bile, ileum, liver, serum, and urine in MMI mice compared to untreated control mice (CT mice) (Supplementary Fig

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GDM is associated with long-lasting complications in the short and long term, such as macrosomia (Song et al., 2022), dystocia (Crowther et al., 2022), childhood obesity in the child (Choi et al., 2022), recurrence of GDM (Giuliani et al., 2022), developing type 2 diabetes (Vounzoulaki et al., 2020) and cardiovascular disease in the mother (Christensen et al., 2022)

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