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Cancer Lett 563:216179 [DOI] [PubMed] [Google Scholar] Choi BSY, Daoust L, Pilon G, Marette A, Tremblay A (2020) Potential therapeutic applications of the gut microbiome in obesity: from brain function to body detoxification

This causal link is supported by robust molecular evidence from models such as the db/db mouse, in which nuclear localization of ATF4 in -cells correlates with diminished insulinotropic responses and accelerated mass loss (Lee et al., 2023) ( Figure 1 , left)

The researchers didnt dive into why GLP-1s may have this impactthey just found a link

Additionally, its only slated to be a temporary offering

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Significant weight loss has traditionally been quantified as total body weight loss of 5 percent or more orforglipron exceeded that in this trial, says Dr