NDPMSH binding melanocortin1 receptor ameliorates neuroinflammation and BBB disruption through CREB/Nr4a1/NFB pathway after intracerebral hemorrhage in mice
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TLR4 activation may lead to ROS signaling via direct interaction between TLR4 and NADPH oxidase (Gill et al., 2010
BMC Genom 17:493 Chen JF, Xu K, Petzer JP, Staal R, Xu YH, Beilstein M, Sonsalla PK, Castagnoli K, Castagnoli N Jr, Schwarzschild MA (2001) Neuroprotection by caffeine and A(2A) adenosine receptor inactivation in a model of Parkinsons disease
In the context of the Melanotan II pathway, this suggests that MC1R-mediated signaling is more likely to function within the expected range, supporting a more typical receptor response to melanocortin-family ligands such as -MSH analogs
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