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This uncertainty does not mean the compound is ineffective or dangerous

N Engl J Med 356(2):125134 Brose MS et al (2014) Sorafenib in radioactive iodine-refractory, locally advanced or metastatic differentiated thyroid cancer: a randomised, double-blind, phase 3 trial

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used by anesthesiologists when providing anesthesia for csections

Because long-term safety data are limited, medical supervision is especially important when combining experimental compounds

Generally, researchers restart the titration schedule with retatrutide regardless of their previous dose, though some experienced practitioners adjust based on their GLP-1 tolerance history