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If both pivotal trials deliver results as strong as or stronger than TRIUMPH-4, Lilly could submit the NDA as early as Q3 2026 rather than Q4, shaving 1 to 3 months off the timeline

Bariatric surgery: Reduces absorptive surface area Bypasses sections of intestine Requires mandatory supplementation GLP-1 therapy: Preserves intestinal anatomy Does not bypass nutrient transporters Alters appetite rather than anatomy The mechanisms differ fundamentally

Health insurance funds in particular fear drastic price increases

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The rate of 1 new approval every 20 to 25 years is inadequate and is in stark contrast with the pace of FDA approvals for diabetes medications, which now outnumber AUD medication approvals 20-fold

doi: 10.1111/ddg.13563_g 36