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Abbreviations A: Amyloid-beta AD: Alzheimer's disease APOE: Apolipoprotein E APP3: Aminopeptidase P3 ARIA: Amyloid-related imaging abnormalities BBB: Bloodbrain barrier CNS: Central nervous system CSF: Cerebrospinal fluid FADD: FAS-associated death domain GABA: Gamma-aminobutyric acid IFN-: Interferon- IKK: IB kinase JNK: C-Jun N-terminal kinase MAPK: Mitogen-activated protein kinase MRI: Magnetic Resonance Imaging mAChR-LTD: Muscarinic acetylcholine receptordependent long-term depression PI3K: Phosphatidylinositol 3-kinase PRh: Perirhinal cortex PMG: Physcion-8-O--d-monoglucoside RA: Rheumatoid arthritis RIP: Receptor-interacting protein solTNF: Soluble tumor necrosis factor tmTNF : Transmembrane tumor necrosis factor TNFR1: Tumor necrosis factor receptor 1 TNFR2: Tumor necrosis factor receptor 2 TNF-: Tumor necrosis factor- TRADD: TNF receptor-associated death domain TRAF2: TNF receptor-associated factor 2 TREM2: Triggering Receptor Expressed on Myeloid Cells 2 WHO: World Health Organization References Global action plan on the public health response to dementia 20172025

The protein expression profile of ACE2 in human tissues