ML226 reduced oxidative phosphorylation, as expected, but prolonged inhibition of ABHD11 was required to induce this reduction, as short-term treatment of CD8 + T cells (24 h) did not alter the oxygen consumption rate (OCR
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Additionally, exposure details are limited to those that were reported to the specialist in poison information at the time of the call and the poison center was unable to verify the accuracy of the report
Dose Escalation: After the initial period, the dose is increasedcommonly to 5 mg once weeklywith further increments (up to a maximum of 15 mg) based on individual response and tolerability
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Am J Pathol 152(4):10491055 Banner W Jr, Koch M, Capin DM, Hopf SB, Chang S, Tong TG (1986) Experimental chelation therapy in chromium, lead, and boron intoxication with N-acetylcysteine and other compounds