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The risks are substantial

Farilla L, Bulotta A, Hirshberg B, Li Calzi S, Khoury N, Noushmehr H, Bertolotto C, Di Mario U, Harlan DM, and Perfetti R

The Cholesterol Treatment Trialists Collaboration analyzed individual data from 19 double-blind randomized trials 123,940 people, followed for a median of 4.5 years

Their effectiveness in managing blood sugar levels has also led to their use in weight loss, with more than 15 million Americans reported using these drugs last month alone, with 40 times more prescriptions being written in 2023 than in 2018

Evidence now extends to fatty liver disease, heart failure, and sleep apnea

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