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This function is mediated via the activation of the cAMP/PKA/CREB (cAMP-responsive element binding protein) and the transactivation of the EGF-R (epidermal growth factor receptor) leading to the activation of phosphatidylinositol-3 kinase (PI3K), protein kinase C(PKC), Akt-protein kinase B (AKT/PKB), extracellular regulated kinase (ERK1/2 or mitogen-activated protein kinase [MAPK]) signaling pathways and to the up-regulation of the expression of the cell cycle regulator cyclinD1 (Figure 3)

doi: 10.1038/s41569-018-0064-2 123 AbergJA

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Moreover, cAMP, the first discovered secondary messenger, can regulate gene expression, protein activity and cell function by altering the level of cAMP, thereby influencing the processes of cell growth, metabolism, differentiation and apoptosis (52)

Asefa M, Hailu T