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Intraarticular Knee Injection Study (2021) Study design : Retrospective review Participants : 16 patients with chronic knee pain Intervention : Intraarticular injection of BPC-157 (2cc of 2000 mcg/mL solution) Follow-up : 6-12 months Results : 14 of 16 patients (87.5%) reported significant pain relief at follow-up
Semaglutide targets GLP-1 only, while tirzepatide targets GLP-1 and GIP
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10.1016/S0140-6736(21)01324-6 63 RyskjaerJ.DeaconC
Contraindications that apply regardless of dose: Personal or family history of medullary thyroid carcinoma (MTC) Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Prior serious hypersensitivity to semaglutide Pregnancy or breastfeeding Active pancreatitis or a history of severe pancreatitis Severe gastroparesis Adverse events that can occur at any dose: nausea, vomiting, diarrhea, constipation, abdominal pain, gallbladder disease, acute kidney injury from dehydration, injection-site reactions, and rare cases of pancreatitis
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