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The main difference is that GSH has an extra hydrogen atom

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The GSH depleting drugs switch the redox state towards an oxidant condition provoking oxidative/nitrosative stress and inflammation, which lead to apoptosis and/or autophagy of the enterocytes

The result: the curcumin actually reaches the places where it is needed

However, upon addition of GSH, driven by favourable enthalpy and unfavourable entrophy 6 , GSH binds within the sub-domain IIA pocket in domain II of BSA (as shown in Supplementary Fig

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