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There are always important caveats to consider when applying knowledge gained from preclinical models, and thus it is important to consider all these issues when designing studies and interpreting results

P21 increased new neurons in the dentate gyrus by 80%

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Pigmented nail lesions can exhibit various colors and sizes, and their origin can be either melanocytic or non-melanocytic.1 In cases of non-melanocytic pigment lesions, such as bacterial or fungal infections and hematomas, clinical findings along with supplementary examinations like dermoscopy, mycological testing, and nail clipping often contribute to a definitive diagnosis.1 Melanocytic pigmentation arises from the deposition of melanin in the nail plate, a condition referred to as true or Longitudinal Melanonychia (LM)

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