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In the case of nicotine, preclinical studies showed evidence that the rewarding effects of nicotine are reduced by stimulation of GLP-1 receptors in the medial habenula, which is a brain region that mediates nicotines aversive effects [48]

Journal of Diabetes Science and Technology, 10 (4), 914922

If you find yourself with significant side effects 24-48 hours after each injection, adjusting the time of day can sometimes shift the peak to a more convenient window