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doi: 135

GLP-1 medications are protein-based biologics susceptible to degradation from temperature extremes, requiring refrigeration between 2C and 8C before opening

by 6 months, 1015% is common

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The FDA has also issued communications regarding unapproved GLP-1 drugs, emphasizing that products containing investigational compounds have not undergone the same review for safety, effectiveness, and quality as approved medications [2]

That number is high enough to plan around if you're sensitive to delivery timelines